Sub-categorization of Pin-II type PIs is provided, based on characteristics like number of IRDs, linker regions, RCLs and disulphide bond architecture. Database analysis showed that alternative processing at linker regions could generate multiple variants of Pin-II type inhibitor proteins. The PINIR database also offers sequence analytical capabilities for further research and thus will facilitate identification of novel Pin-II type PI sequences.

Details of Pin-II type PI family:

MEROPS ID :  I20    Pfam ID :  PF02428    InterPro ID :  IPR003465   

Citation : Yadav, N.K., Saikhedkar, N.S. & Giri, A.P. PINIR: a comprehensive information resource for Pin-II type protease inhibitors. BMC Plant Biol 21, 267 (2021).