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Domains (IRDs)
Reactive Loops (RCL)
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Target Protease
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Domains (IRDs)
Reactive Loops (RCL)
Linkers
Target Protease
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Domain Details
Domain List
IRD-25
Overview
RCL/Linker
Disulphide Bonds
Amino acid (aa) Composition
Domain Type
No. Of PIs
No. of DS Bonds
No. of Species
H+L Type (Type-III)
3
4
1
Sequence
Reactive Loop
Linker
GICINCCSGFKECKYFSKDYTLICDGESKDWESRKA
CSKEC
DRRIEFGICVTD
REACTIVE LOOPS
Entry
RCL
Position
Target Protease
RL-13
CSKEC
37 - 41
Trypsin
Linkers
Entry
Linker
Position
Type
Disulphide Bonds
Bond No.
Position
Bond 1
3 - 41
Bond 2
6 - 24
Bond 3
7 - 37
Bond 4
13 - 50
Architecture
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
G
I
C
I
N
C
C
S
G
F
K
E
C
K
Y
F
S
K
D
Y
T
L
I
C
D
G
E
S
K
D
W
E
S
R
K
A
C
S
K
E
C
D
R
R
I
E
F
G
I
C
V
T
D
Amino Acid
Count
Percentage
Alanine
1
1.886792453
Cysteine
8
15.09433962
Aspartic acid
5
9.433962264
Glutamic acid
5
9.433962264
Phenylalanine
3
5.660377358
Glycine
4
7.547169811
Histidine
0
0
Isoleucine
5
9.433962264
Lysine
6
11.32075472
Leucine
1
1.886792453
Methionine
0
0
Asparagine
1
1.886792453
Proline
0
0
Glutamine
0
0
Arginine
3
5.660377358
Serine
5
9.433962264
Threonine
2
3.773584906
Valine
1
1.886792453
Tryptophan
1
1.886792453
Tyrosine
2
3.773584906