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Reactive Loops (RCL)
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Domains (IRDs)
Reactive Loops (RCL)
Linkers
Target Protease
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Domain Details
Domain List
IRD-8
Overview
RCL/Linker
Disulphide Bonds
Amino acid (aa) Composition
Domain Type
No. Of PIs
No. of DS Bonds
No. of Species
H+L Type (Type-III)
1
4
1
Sequence
Reactive Loop
Linker
VGCTNCCSGTEGCNYFSANGTFICEGQTKKTIDETNKV
CPFNC
NPRIAYSICPGN
REACTIVE LOOPS
Entry
RCL
Position
Target Protease
RL-5
CPFNC
39 - 43
Chymotrypsin
Linkers
Entry
Linker
Position
Type
Disulphide Bonds
Bond No.
Position
Bond 1
3 - 43
Bond 2
6 - 24
Bond 3
7 - 39
Bond 4
13 - 52
Architecture
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
V
G
C
T
N
C
C
S
G
T
E
G
C
N
Y
F
S
A
N
G
T
F
I
C
E
G
Q
T
K
K
T
I
D
E
T
N
K
V
C
P
F
N
C
N
P
R
I
A
Y
S
I
C
P
G
N
Amino Acid
Count
Percentage
Alanine
2
3.636363636
Cysteine
8
14.54545455
Aspartic acid
1
1.818181818
Glutamic acid
3
5.454545455
Phenylalanine
3
5.454545455
Glycine
6
10.90909091
Histidine
0
0
Isoleucine
4
7.272727273
Lysine
3
5.454545455
Leucine
0
0
Methionine
0
0
Asparagine
7
12.72727273
Proline
3
5.454545455
Glutamine
1
1.818181818
Arginine
1
1.818181818
Serine
3
5.454545455
Threonine
6
10.90909091
Valine
2
3.636363636
Tryptophan
0
0
Tyrosine
2
3.636363636