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Proteins
Proteins (PIs)
Proteins details
PINIR_164
[
Q1WL37
] :
Trypsin proteinase inhibitor
147
Length
Nicotiana corymbosa
Specie
PI
Gene Name
16209
Mass
3
Domain Count
Overview
Function
Domains
Amino acid (aa) Composition
Visualization
Sequence :
FASTA Sequence copied to clipboard!
×
FASTA
MAVHRVSFLA
FLLLFGMSLL
VNNVEHADAK
ACPFNCDPRI
AYGVCPRSEE
KKNNQICTNC
CAGTKGCNYF
70
SADGTFVCKG
ESDPRNPKAC
PRNCDPRIDY
RVCPRSEEKD
NQICTNCCAG
TKGCNYFSAN
GTFICEGESE
140
YVSKVDE
147
SIGNAL PEPTIDE
SEQUENCE
Position
MAVHRVSFLAFLLLFGMSLLVNNVEHADA
1 ↔ 29
DISULPHIDE BOND
Disulfidebondtype
Position
Disulfide bond 1
3 ↔ 27
Disulfide bond 1
3 ↔ 28
Disulfide bond 1
3 ↔ 40
Disulfide bond 2
6 ↔ 24
Disulfide bond 2
7 ↔ 31
Disulfide bond 2
7 ↔ 32
Disulfide bond 3
7 ↔ 36
Disulfide bond 3
16 ↔ 37
Disulfide bond 3
16 ↔ 38
Disulfide bond 4
13 ↔ 49
Disulfide bond 4
30 ↔ 48
Disulfide bond 4
31 ↔ 49
DOMAINS ARCHITECTURE
View diagram
Domain
Position
Length
Architecture
IRD-176
55 - 106
52
IRD-577
88 - 137
50
IRD-666
30 - 80
51
ISO - ELECTRIC POINT
Iso Eelectric Point
charge at pH 7.4
charge at pH 5.5
charge at pH 8.0
5.845
1
-7.8
-13.6
CROSS REFERENCES
Uniprot
Interpro Id
Pfam Id
EMBL
Q1WL37
View PI in InterPro
IPR003465
View protein in Pfam
PF02428
DQ158195
REFERENCES
PubMed ID:
16534618
|
Application:
REACTIVE LOOPS
Entry
RCL Sequence
Target Protease
Position
RL-1
CPRNC
Trypsin
91 - 95
RL-1
CPRNC
Trypsin
91 - 95
RL-5
CPFNC
Chymotrypsin
33 - 37
GO TERMS
Molecular Function
Cellular Component
Biological Process
serine-type endopeptidase inhibitor activity (GO:0004867)
None
None
SPATIO TEMPORAL DISTRIBUTION
Tissue Distribution
Induction
Elicitor Molecules
Target Insect
Remarks
Reference
No Records Found
BIO-CHEMICAL PROPERTIES
Ki (uM)
IC50 (uM)
Target Protease
Cross Reactivity
Remarks
Reference
No Records Found
BIO-PHYSICAL PROPERTIES
Affinity
Binding Energy
Stability
Remarks
Reference
No Records Found
DOMAIN STRUCTURE FOLD
Beta Sheet Numbers
Alpha Helix Numbers
Coil Numbers
Disulphide Bonds Numbers
Remarks
Reference
No Records Found
Entry
Domain Position
RCL
RCL Position
Linker
Linker Position
Domain Type
IRD-176
55 - 106
CPRNC
90 - 94
DPRNP
83 - 87
H-L Type (Type-I)
IRD-577
88 - 137
CPRNC
90 - 94
EEKDN
107 - 111
L-H Type (Type-II)
IRD-666
30 - 80
CPFNC
32 - 36
EEKKN
49 - 53
L-H Type (Type-II)
Domain(
IRD-176
)
:
QICTNCCAGTKGCNYFSADGTFVCKGES
DPRNP
KA
CPRNC
DPRIDYRVCPRS
Reactive Loop(RCL)
:
CPRNC
Linker
:
DPRNP
Domain Type
:
H-L Type (Type-I)
Disulphide Bond
:
3,40 ; 6,24 ; 7,36 ; 13,49
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
Q
I
C
T
N
C
C
A
G
T
K
G
C
N
Y
F
S
A
D
G
T
F
V
C
K
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
D
Y
R
V
C
P
R
S
Domain(
IRD-577
)
:
KA
CPRNC
DPRIDYRVCPRS
EEKDN
QICTNCCAGTKGCNYFSANGTFICEG
Reactive Loop(RCL)
:
CPRNC
Linker
:
EEKDN
Domain Type
:
L-H Type (Type-II)
Disulphide Bond
:
3,27 ; 7,31 ; 16,37 ; 30,48
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
K
A
C
P
R
N
C
D
P
R
I
D
Y
R
V
C
P
R
S
E
E
K
D
N
Q
I
C
T
N
C
C
A
G
T
K
G
C
N
Y
F
S
A
N
G
T
F
I
C
E
G
Domain(
IRD-666
)
:
KA
CPFNC
DPRIAYGVCPRS
EEKKN
NQICTNCCAGTKGCNYFSADGTFVCKG
Reactive Loop(RCL)
:
CPFNC
Linker
:
EEKKN
Domain Type
:
L-H Type (Type-II)
Disulphide Bond
:
3,28 ; 7,32 ; 16,38 ; 31,49
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
K
A
C
P
F
N
C
D
P
R
I
A
Y
G
V
C
P
R
S
E
E
K
K
N
N
Q
I
C
T
N
C
C
A
G
T
K
G
C
N
Y
F
S
A
D
G
T
F
V
C
K
G
DOMAINS ARCHITECTURE
Domain
Position
Length
Architecture
IRD-176
55 - 106
52
IRD-577
88 - 137
50
IRD-666
30 - 80
51
Amino Acid
Count
% by Frequency
Alanine
11
7.48
Cysteine
16
10.88
Aspartic acid
8
5.44
Glutamic acid
10
6.8
Phenylalanine
8
5.44
Glycine
10
6.8
Histidine
2
1.36
Isoleucine
5
3.4
Lysine
9
6.12
Leucine
6
4.08
Methionine
2
1.36
Asparagine
13
8.84
Proline
8
5.44
Glutamine
2
1.36
Arginine
8
5.44
Serine
9
6.12
Threonine
6
4.08
Valine
9
6.12
Tryptophan
0
0
Tyrosine
5
3.4
Architecture
×
Signal Peptide
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
M
A
V
H
R
V
S
F
L
A
F
L
L
L
F
G
M
S
L
L
V
N
N
V
E
H
A
D
A
K
A
C
P
F
N
C
D
P
R
I
A
Y
G
V
C
P
R
S
E
E
K
K
N
N
Q
I
C
T
N
C
C
A
G
T
K
G
C
N
Y
F
S
A
D
G
T
F
V
C
K
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
D
Y
R
V
C
P
R
S
E
E
K
D
N
Q
I
C
T
N
C
C
A
G
T
K
G
C
N
Y
F
S
A
N
G
T
F
I
C
E
G
E
S
E
Y
V
S
K
V
D
E
A
V
H
R
V
S
F
L
A
F
L
L
L
F
G
M
S
L
L
V
N
N
V
E
H
A
D
A
K
Domains
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
M
A
V
H
R
V
S
F
L
A
F
L
L
L
F
G
M
S
L
L
V
N
N
V
E
H
A
D
A
K
A
C
P
F
N
C
D
P
R
I
A
Y
G
V
C
P
R
S
E
E
K
K
N
N
Q
I
C
T
N
C
C
A
G
T
K
G
C
N
Y
F
S
A
D
G
T
F
V
C
K
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
D
Y
R
V
C
P
R
S
E
E
K
D
N
Q
I
C
T
N
C
C
A
G
T
K
G
C
N
Y
F
S
A
N
G
T
F
I
C
E
G
E
S
E
Y
V
S
K
V
D
E
