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Proteins
Proteins (PIs)
Proteins details
PINIR_45
[
A0A1U7Y2F0
] :
uncharacterized protein LOC104239916
434
Length
Nicotiana sylvestris
Specie
LOC104239916
Gene Name
47793
Mass
13
Domain Count
Overview
Function
Domains
Amino acid (aa) Composition
Visualization
Sequence :
FASTA Sequence copied to clipboard!
×
FASTA
MAVHRVNFLA
FLLLFGMSLL
VNNVEHADAK
ACSFNCDPRI
AYGVCPRSEE
KKNNQICTNC
CAGTKGCNYF
70
SADGTFVCEG
QFDPRNPKAC
PRNCDPRIAY
GVCPRSKEKK
DNQICTNCCA
GTKGCNYFSA
DGTFVCEGEF
140
DPRNPKACPR
NCDPRIAYGV
CPRSKEKKDN
QICTNCCAGT
KGCNYFSADG
TFVCKGESDP
RNPKACPRNC
210
DPRIDYRVCP
RSEEKDNQIC
TNCCAGMKGC
NYFSADGTFV
CKGESDPRNP
KACPRNCDPR
IAYGVCPRSE
280
EKDNQICTNC
CAGTKGCNYF
SADGTFVCKG
ESDPRNPKAC
PRNCDPRIDY
RVCPRSEEKN
NQICTNCCAG
350
TKGCNYFSAD
GTFVCEGESD
PRNPKACPRN
CDPRIDYRVC
PYSEEKNNQI
CTNCCAGTKG
CNYFSANGTF
420
ICNGESEYIS
KVDE
434
SIGNAL PEPTIDE
SEQUENCE
Position
MAVHRVNFLAFLLLFGMSLLVNNVEHADA
1 ↔ 29
DISULPHIDE BOND
Disulfidebondtype
Position
Disulfide bond 1
3 ↔ 27
Disulfide bond 1
3 ↔ 28
Disulfide bond 1
3 ↔ 40
Disulfide bond 2
6 ↔ 24
Disulfide bond 2
7 ↔ 31
Disulfide bond 2
7 ↔ 32
Disulfide bond 3
7 ↔ 36
Disulfide bond 3
16 ↔ 37
Disulfide bond 3
16 ↔ 38
Disulfide bond 4
13 ↔ 49
Disulfide bond 4
30 ↔ 48
Disulfide bond 4
31 ↔ 49
DOMAINS ARCHITECTURE
View diagram
Domain
Position
Length
Architecture
IRD-174
55 - 106
52
IRD-175
113 - 164
52
IRD-176
171 - 222
52
IRD-176
285 - 336
52
IRD-177
228 - 279
52
IRD-178
342 - 393
52
IRD-565
88 - 138
51
IRD-566
146 - 196
51
IRD-567
204 - 253
50
IRD-568
261 - 310
50
IRD-582
318 - 367
50
IRD-583
375 - 424
50
IRD-675
30 - 80
51
ISO - ELECTRIC POINT
Iso Eelectric Point
charge at pH 7.4
charge at pH 5.5
charge at pH 8.0
6.976
10.1
-16.7
-36.7
CROSS REFERENCES
Uniprot
Interpro Id
Pfam Id
EMBL
A0A1U7Y2F0
View PI in InterPro
IPR003465
View protein in Pfam
PF02428
REFERENCES
PubMed ID:
23773524
|
Application:
REACTIVE LOOPS
Entry
RCL Sequence
Target Protease
Position
RL-1
CPRNC
Trypsin
91 - 95
RL-1
CPRNC
Trypsin
91 - 95
RL-1
CPRNC
Trypsin
149 - 153
RL-1
CPRNC
Trypsin
149 - 153
RL-1
CPRNC
Trypsin
207 - 211
RL-1
CPRNC
Trypsin
207 - 211
RL-1
CPRNC
Trypsin
264 - 268
RL-1
CPRNC
Trypsin
264 - 268
RL-1
CPRNC
Trypsin
321 - 325
RL-1
CPRNC
Trypsin
321 - 325
RL-1
CPRNC
Trypsin
378 - 382
RL-1
CPRNC
Trypsin
378 - 382
RL-45
CSFNC
Chymotrypsin
33 - 37
GO TERMS
Molecular Function
Cellular Component
Biological Process
serine-type endopeptidase inhibitor activity (GO:0004867)
None
None
SPATIO TEMPORAL DISTRIBUTION
Tissue Distribution
Induction
Elicitor Molecules
Target Insect
Remarks
Reference
No Records Found
BIO-CHEMICAL PROPERTIES
Ki (uM)
IC50 (uM)
Target Protease
Cross Reactivity
Remarks
Reference
No Records Found
BIO-PHYSICAL PROPERTIES
Affinity
Binding Energy
Stability
Remarks
Reference
No Records Found
DOMAIN STRUCTURE FOLD
Beta Sheet Numbers
Alpha Helix Numbers
Coil Numbers
Disulphide Bonds Numbers
Remarks
Reference
No Records Found
Entry
Domain Position
RCL
RCL Position
Linker
Linker Position
Domain Type
IRD-174
55 - 106
CPRNC
90 - 94
DPRNP
83 - 87
H-L Type (Type-I)
IRD-175
113 - 164
CPRNC
148 - 152
DPRNP
141 - 145
H-L Type (Type-I)
IRD-176
171 - 222
CPRNC
206 - 210
DPRNP
199 - 203
H-L Type (Type-I)
IRD-176
285 - 336
CPRNC
320 - 324
DPRNP
313 - 317
H-L Type (Type-I)
IRD-177
228 - 279
CPRNC
263 - 267
DPRNP
256 - 260
H-L Type (Type-I)
IRD-178
342 - 393
CPRNC
377 - 381
DPRNP
370 - 374
H-L Type (Type-I)
IRD-565
88 - 138
CPRNC
90 - 94
EKKDN
108 - 112
L-H Type (Type-II)
IRD-566
146 - 196
CPRNC
148 - 152
EKKDN
166 - 170
L-H Type (Type-II)
IRD-567
204 - 253
CPRNC
206 - 210
EEKDN
223 - 227
L-H Type (Type-II)
IRD-568
261 - 310
CPRNC
263 - 267
EEKDN
280 - 284
L-H Type (Type-II)
IRD-582
318 - 367
CPRNC
320 - 324
EEKNN
337 - 341
L-H Type (Type-II)
IRD-583
375 - 424
CPRNC
377 - 381
EEKNN
394 - 398
L-H Type (Type-II)
IRD-675
30 - 80
CSFNC
32 - 36
EEKKN
49 - 53
L-H Type (Type-II)
Domain(
IRD-174
)
:
QICTNCCAGTKGCNYFSADGTFVCEGQF
DPRNP
KA
CPRNC
DPRIAYGVCPRS
Reactive Loop(RCL)
:
CPRNC
Linker
:
DPRNP
Domain Type
:
H-L Type (Type-I)
Disulphide Bond
:
3,40 ; 6,24 ; 7,36 ; 13,49
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
Q
I
C
T
N
C
C
A
G
T
K
G
C
N
Y
F
S
A
D
G
T
F
V
C
E
G
Q
F
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
V
C
P
R
S
Domain(
IRD-175
)
:
QICTNCCAGTKGCNYFSADGTFVCEGEF
DPRNP
KA
CPRNC
DPRIAYGVCPRS
Reactive Loop(RCL)
:
CPRNC
Linker
:
DPRNP
Domain Type
:
H-L Type (Type-I)
Disulphide Bond
:
3,40 ; 6,24 ; 7,36 ; 13,49
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
Q
I
C
T
N
C
C
A
G
T
K
G
C
N
Y
F
S
A
D
G
T
F
V
C
E
G
E
F
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
V
C
P
R
S
Domain(
IRD-176
)
:
QICTNCCAGTKGCNYFSADGTFVCKGES
DPRNP
KA
CPRNC
DPRIDYRVCPRS
Reactive Loop(RCL)
:
CPRNC
Linker
:
DPRNP
Domain Type
:
H-L Type (Type-I)
Disulphide Bond
:
3,40 ; 6,24 ; 7,36 ; 13,49
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
Q
I
C
T
N
C
C
A
G
T
K
G
C
N
Y
F
S
A
D
G
T
F
V
C
K
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
D
Y
R
V
C
P
R
S
Domain(
IRD-176
)
:
QICTNCCAGTKGCNYFSADGTFVCKGES
DPRNP
KA
CPRNC
DPRIDYRVCPRS
Reactive Loop(RCL)
:
CPRNC
Linker
:
DPRNP
Domain Type
:
H-L Type (Type-I)
Disulphide Bond
:
3,40 ; 6,24 ; 7,36 ; 13,49
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
Q
I
C
T
N
C
C
A
G
T
K
G
C
N
Y
F
S
A
D
G
T
F
V
C
K
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
D
Y
R
V
C
P
R
S
Domain(
IRD-177
)
:
QICTNCCAGMKGCNYFSADGTFVCKGES
DPRNP
KA
CPRNC
DPRIAYGVCPRS
Reactive Loop(RCL)
:
CPRNC
Linker
:
DPRNP
Domain Type
:
H-L Type (Type-I)
Disulphide Bond
:
3,40 ; 6,24 ; 7,36 ; 13,49
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
Q
I
C
T
N
C
C
A
G
M
K
G
C
N
Y
F
S
A
D
G
T
F
V
C
K
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
V
C
P
R
S
Domain(
IRD-178
)
:
QICTNCCAGTKGCNYFSADGTFVCEGES
DPRNP
KA
CPRNC
DPRIDYRVCPYS
Reactive Loop(RCL)
:
CPRNC
Linker
:
DPRNP
Domain Type
:
H-L Type (Type-I)
Disulphide Bond
:
3,40 ; 6,24 ; 7,36 ; 13,49
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
Q
I
C
T
N
C
C
A
G
T
K
G
C
N
Y
F
S
A
D
G
T
F
V
C
E
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
D
Y
R
V
C
P
Y
S
Domain(
IRD-565
)
:
KA
CPRNC
DPRIAYGVCPRSK
EKKDN
QICTNCCAGTKGCNYFSADGTFVCEG
Reactive Loop(RCL)
:
CPRNC
Linker
:
EKKDN
Domain Type
:
L-H Type (Type-II)
Disulphide Bond
:
3,28 ; 7,32 ; 16,38 ; 31,49
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
V
C
P
R
S
K
E
K
K
D
N
Q
I
C
T
N
C
C
A
G
T
K
G
C
N
Y
F
S
A
D
G
T
F
V
C
E
G
Domain(
IRD-566
)
:
KA
CPRNC
DPRIAYGVCPRSK
EKKDN
QICTNCCAGTKGCNYFSADGTFVCKG
Reactive Loop(RCL)
:
CPRNC
Linker
:
EKKDN
Domain Type
:
L-H Type (Type-II)
Disulphide Bond
:
3,28 ; 7,32 ; 16,38 ; 31,49
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
V
C
P
R
S
K
E
K
K
D
N
Q
I
C
T
N
C
C
A
G
T
K
G
C
N
Y
F
S
A
D
G
T
F
V
C
K
G
Domain(
IRD-567
)
:
KA
CPRNC
DPRIDYRVCPRS
EEKDN
QICTNCCAGMKGCNYFSADGTFVCKG
Reactive Loop(RCL)
:
CPRNC
Linker
:
EEKDN
Domain Type
:
L-H Type (Type-II)
Disulphide Bond
:
3,27 ; 7,31 ; 16,37 ; 30,48
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
K
A
C
P
R
N
C
D
P
R
I
D
Y
R
V
C
P
R
S
E
E
K
D
N
Q
I
C
T
N
C
C
A
G
M
K
G
C
N
Y
F
S
A
D
G
T
F
V
C
K
G
Domain(
IRD-568
)
:
KA
CPRNC
DPRIAYGVCPRS
EEKDN
QICTNCCAGTKGCNYFSADGTFVCKG
Reactive Loop(RCL)
:
CPRNC
Linker
:
EEKDN
Domain Type
:
L-H Type (Type-II)
Disulphide Bond
:
3,27 ; 7,31 ; 16,37 ; 30,48
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
V
C
P
R
S
E
E
K
D
N
Q
I
C
T
N
C
C
A
G
T
K
G
C
N
Y
F
S
A
D
G
T
F
V
C
K
G
Domain(
IRD-582
)
:
KA
CPRNC
DPRIDYRVCPRS
EEKNN
QICTNCCAGTKGCNYFSADGTFVCEG
Reactive Loop(RCL)
:
CPRNC
Linker
:
EEKNN
Domain Type
:
L-H Type (Type-II)
Disulphide Bond
:
3,27 ; 7,31 ; 16,37 ; 30,48
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
K
A
C
P
R
N
C
D
P
R
I
D
Y
R
V
C
P
R
S
E
E
K
N
N
Q
I
C
T
N
C
C
A
G
T
K
G
C
N
Y
F
S
A
D
G
T
F
V
C
E
G
Domain(
IRD-583
)
:
KA
CPRNC
DPRIDYRVCPYS
EEKNN
QICTNCCAGTKGCNYFSANGTFICNG
Reactive Loop(RCL)
:
CPRNC
Linker
:
EEKNN
Domain Type
:
L-H Type (Type-II)
Disulphide Bond
:
3,27 ; 7,31 ; 16,37 ; 30,48
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
K
A
C
P
R
N
C
D
P
R
I
D
Y
R
V
C
P
Y
S
E
E
K
N
N
Q
I
C
T
N
C
C
A
G
T
K
G
C
N
Y
F
S
A
N
G
T
F
I
C
N
G
Domain(
IRD-675
)
:
KA
CSFNC
DPRIAYGVCPRS
EEKKN
NQICTNCCAGTKGCNYFSADGTFVCEG
Reactive Loop(RCL)
:
CSFNC
Linker
:
EEKKN
Domain Type
:
L-H Type (Type-II)
Disulphide Bond
:
3,28 ; 7,32 ; 16,38 ; 31,49
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
K
A
C
S
F
N
C
D
P
R
I
A
Y
G
V
C
P
R
S
E
E
K
K
N
N
Q
I
C
T
N
C
C
A
G
T
K
G
C
N
Y
F
S
A
D
G
T
F
V
C
E
G
DOMAINS ARCHITECTURE
Domain
Position
Length
Architecture
IRD-174
55 - 106
52
IRD-175
113 - 164
52
IRD-176
171 - 222
52
IRD-176
285 - 336
52
IRD-177
228 - 279
52
IRD-178
342 - 393
52
IRD-565
88 - 138
51
IRD-566
146 - 196
51
IRD-567
204 - 253
50
IRD-568
261 - 310
50
IRD-582
318 - 367
50
IRD-583
375 - 424
50
IRD-675
30 - 80
51
Amino Acid
Count
% by Frequency
Alanine
29
6.68
Cysteine
56
12.9
Aspartic acid
28
6.45
Glutamic acid
24
5.53
Phenylalanine
20
4.61
Glycine
33
7.6
Histidine
2
0.46
Isoleucine
16
3.69
Lysine
30
6.91
Leucine
6
1.38
Methionine
3
0.69
Asparagine
42
9.68
Proline
32
7.37
Glutamine
8
1.84
Arginine
29
6.68
Serine
22
5.07
Threonine
20
4.61
Valine
18
4.15
Tryptophan
0
0
Tyrosine
16
3.69
Architecture
×
Signal Peptide
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298
299
300
301
302
303
304
305
306
307
308
309
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
352
353
354
355
356
357
358
359
360
361
362
363
364
365
366
367
368
369
370
371
372
373
374
375
376
377
378
379
380
381
382
383
384
385
386
387
388
389
390
391
392
393
394
395
396
397
398
399
400
401
402
403
404
405
406
407
408
409
410
411
412
413
414
415
416
417
418
419
420
421
422
423
424
425
426
427
428
429
430
431
432
433
434
M
A
V
H
R
V
N
F
L
A
F
L
L
L
F
G
M
S
L
L
V
N
N
V
E
H
A
D
A
K
A
C
S
F
N
C
D
P
R
I
A
Y
G
V
C
P
R
S
E
E
K
K
N
N
Q
I
C
T
N
C
C
A
G
T
K
G
C
N
Y
F
S
A
D
G
T
F
V
C
E
G
Q
F
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
V
C
P
R
S
K
E
K
K
D
N
Q
I
C
T
N
C
C
A
G
T
K
G
C
N
Y
F
S
A
D
G
T
F
V
C
E
G
E
F
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
V
C
P
R
S
K
E
K
K
D
N
Q
I
C
T
N
C
C
A
G
T
K
G
C
N
Y
F
S
A
D
G
T
F
V
C
K
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
D
Y
R
V
C
P
R
S
E
E
K
D
N
Q
I
C
T
N
C
C
A
G
M
K
G
C
N
Y
F
S
A
D
G
T
F
V
C
K
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
V
C
P
R
S
E
E
K
D
N
Q
I
C
T
N
C
C
A
G
T
K
G
C
N
Y
F
S
A
D
G
T
F
V
C
K
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
D
Y
R
V
C
P
R
S
E
E
K
N
N
Q
I
C
T
N
C
C
A
G
T
K
G
C
N
Y
F
S
A
D
G
T
F
V
C
E
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
D
Y
R
V
C
P
Y
S
E
E
K
N
N
Q
I
C
T
N
C
C
A
G
T
K
G
C
N
Y
F
S
A
N
G
T
F
I
C
N
G
E
S
E
Y
I
S
K
V
D
E
A
V
H
R
V
N
F
L
A
F
L
L
L
F
G
M
S
L
L
V
N
N
V
E
H
A
D
A
K
Domains
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298
299
300
301
302
303
304
305
306
307
308
309
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
352
353
354
355
356
357
358
359
360
361
362
363
364
365
366
367
368
369
370
371
372
373
374
375
376
377
378
379
380
381
382
383
384
385
386
387
388
389
390
391
392
393
394
395
396
397
398
399
400
401
402
403
404
405
406
407
408
409
410
411
412
413
414
415
416
417
418
419
420
421
422
423
424
425
426
427
428
429
430
431
432
433
434
M
A
V
H
R
V
N
F
L
A
F
L
L
L
F
G
M
S
L
L
V
N
N
V
E
H
A
D
A
K
A
C
S
F
N
C
D
P
R
I
A
Y
G
V
C
P
R
S
E
E
K
K
N
N
Q
I
C
T
N
C
C
A
G
T
K
G
C
N
Y
F
S
A
D
G
T
F
V
C
E
G
Q
F
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
V
C
P
R
S
K
E
K
K
D
N
Q
I
C
T
N
C
C
A
G
T
K
G
C
N
Y
F
S
A
D
G
T
F
V
C
E
G
E
F
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
V
C
P
R
S
K
E
K
K
D
N
Q
I
C
T
N
C
C
A
G
T
K
G
C
N
Y
F
S
A
D
G
T
F
V
C
K
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
D
Y
R
V
C
P
R
S
E
E
K
D
N
Q
I
C
T
N
C
C
A
G
M
K
G
C
N
Y
F
S
A
D
G
T
F
V
C
K
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
V
C
P
R
S
E
E
K
D
N
Q
I
C
T
N
C
C
A
G
T
K
G
C
N
Y
F
S
A
D
G
T
F
V
C
K
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
D
Y
R
V
C
P
R
S
E
E
K
N
N
Q
I
C
T
N
C
C
A
G
T
K
G
C
N
Y
F
S
A
D
G
T
F
V
C
E
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
D
Y
R
V
C
P
Y
S
E
E
K
N
N
Q
I
C
T
N
C
C
A
G
T
K
G
C
N
Y
F
S
A
N
G
T
F
I
C
N
G
E
S
E
Y
I
S
K
V
D
E