Home
Browse
Proteins (PIs)
Domains (IRDs)
Reactive Loops (RCL)
Linkers
Target Protease
Taxonomy
Domain Architecture
Data Analysis
Proteins (PIs)
Domains (IRDs)
Reactive Loops (RCL)
Linkers
Target Protease
Search
Downloads
Contact Us
Proteins
Proteins (PIs)
Proteins details
PINIR_67
[
A0A1U7WDA6
] :
uncharacterized protein LOC104227417
687
Length
Nicotiana sylvestris
Specie
LOC104227417
Gene Name
75345
Mass
21
Domain Count
Overview
Function
Domains
Amino acid (aa) Composition
Visualization
Sequence :
FASTA Sequence copied to clipboard!
×
FASTA
MAVHRVSFLA
LLLLLGMSLL
VSNVEHADAK
ACPLNCDPRI
AYGVCPRSEE
KKNDRICTNC
CAGTKGCKYF
70
SDDGTFVCEG
ESDPRNPKAC
PRNCDPRIAY
GICPLSEEKK
NDRICTNCCA
GTKGCKYFSD
DGTFVCEGES
140
DPRNPKACPR
NCDPRIAYGI
CPLSEEKKND
RICTNCCAGT
KGCKYFSDDG
TFVCEGESDP
RNPKACPRNC
210
DPRIAYGICP
LSEEKKNDRI
CTNCCAGTKG
CKYFSDDGTF
VCEGESDPRN
PKACPRNCDP
RIAYGICPLS
280
EEKKNDRICT
NCCAGTKGCK
YFSDDGTFVC
EGESDPRNPK
ACPRNCDPRI
AYGICPLSEE
KKNDRICTNC
350
CAGTKGCKYF
SDDGTFVCEG
ESDPRNPKAC
PRNCDPRIAY
GICPLSEEKK
NDRICTNCCA
GTKGCKYFSD
420
DGTFVCEGES
DPRNPKACPR
NCDPRIAYGI
CPLSEEKKND
RICTNCCAGT
KGCKYFSDDG
TFVCEGESDP
490
RNPKACPRNC
DPRIAYGICP
LSEEKKNDRI
CTNCCAGTKG
CKYFSNDGTF
VCEGESDPRN
PKACTLNCDP
560
RIAYGICPLS
EEKKNDRICT
NCCAGKKGCK
YFSDDGTFVC
EGESDPRNPK
ACPRNCDGRI
AYGICPLSEE
630
KKNDRICTNC
CAGKKGCKYF
SDDGTFICEG
ESEYASKVDE
YVREVENDLQ
KSKVAVS
687
SIGNAL PEPTIDE
SEQUENCE
Position
MAVHRVSFLALLLLLGMSLLVSNVEHADA
1 ↔ 29
DISULPHIDE BOND
Disulfidebondtype
Position
Disulfide bond 1
3 ↔ 28
Disulfide bond 1
3 ↔ 40
Disulfide bond 2
6 ↔ 24
Disulfide bond 2
7 ↔ 32
Disulfide bond 3
7 ↔ 36
Disulfide bond 3
16 ↔ 38
Disulfide bond 4
13 ↔ 49
Disulfide bond 4
31 ↔ 49
DOMAINS ARCHITECTURE
View diagram
Domain
Position
Length
Architecture
IRD-152
229 - 280
52
IRD-152
171 - 222
52
IRD-152
461 - 512
52
IRD-152
113 - 164
52
IRD-152
403 - 454
52
IRD-152
55 - 106
52
IRD-152
345 - 396
52
IRD-152
287 - 338
52
IRD-153
577 - 628
52
IRD-251
519 - 570
52
IRD-604
262 - 312
51
IRD-604
204 - 254
51
IRD-604
146 - 196
51
IRD-604
436 - 486
51
IRD-604
88 - 138
51
IRD-604
378 - 428
51
IRD-604
320 - 370
51
IRD-605
494 - 544
51
IRD-606
610 - 660
51
IRD-655
30 - 80
51
IRD-658
552 - 602
51
ISO - ELECTRIC POINT
Iso Eelectric Point
charge at pH 7.4
charge at pH 5.5
charge at pH 8.0
5.869
4.4
-38.5
-70.7
CROSS REFERENCES
Uniprot
Interpro Id
Pfam Id
EMBL
A0A1U7WDA6
View PI in InterPro
IPR003465
View protein in Pfam
PF02428
REFERENCES
PubMed ID:
23773524
|
Application:
REACTIVE LOOPS
Entry
RCL Sequence
Target Protease
Position
RL-1
CPRNC
Trypsin
91 - 95
RL-1
CPRNC
Trypsin
91 - 95
RL-1
CPRNC
Trypsin
149 - 153
RL-1
CPRNC
Trypsin
149 - 153
RL-1
CPRNC
Trypsin
207 - 211
RL-1
CPRNC
Trypsin
207 - 211
RL-1
CPRNC
Trypsin
265 - 269
RL-1
CPRNC
Trypsin
265 - 269
RL-1
CPRNC
Trypsin
323 - 327
RL-1
CPRNC
Trypsin
323 - 327
RL-1
CPRNC
Trypsin
381 - 385
RL-1
CPRNC
Trypsin
381 - 385
RL-1
CPRNC
Trypsin
439 - 443
RL-1
CPRNC
Trypsin
439 - 443
RL-1
CPRNC
Trypsin
497 - 501
RL-1
CPRNC
Trypsin
497 - 501
RL-1
CPRNC
Trypsin
613 - 617
RL-1
CPRNC
Trypsin
613 - 617
RL-2
CPLNC
Chymotrypsin
33 - 37
RL-3
CTLNC
Chymotrypsin
555 - 559
RL-3
CTLNC
Chymotrypsin
555 - 559
GO TERMS
Molecular Function
Cellular Component
Biological Process
serine-type endopeptidase inhibitor activity (GO:0004867)
None
None
SPATIO TEMPORAL DISTRIBUTION
Tissue Distribution
Induction
Elicitor Molecules
Target Insect
Remarks
Reference
No Records Found
BIO-CHEMICAL PROPERTIES
Ki (uM)
IC50 (uM)
Target Protease
Cross Reactivity
Remarks
Reference
No Records Found
BIO-PHYSICAL PROPERTIES
Affinity
Binding Energy
Stability
Remarks
Reference
No Records Found
DOMAIN STRUCTURE FOLD
Beta Sheet Numbers
Alpha Helix Numbers
Coil Numbers
Disulphide Bonds Numbers
Remarks
Reference
No Records Found
Entry
Domain Position
RCL
RCL Position
Linker
Linker Position
Domain Type
IRD-152
229 - 280
CPRNC
264 - 268
DPRNP
257 - 261
H-L Type (Type-I)
IRD-152
171 - 222
CPRNC
206 - 210
DPRNP
199 - 203
H-L Type (Type-I)
IRD-152
461 - 512
CPRNC
496 - 500
DPRNP
489 - 493
H-L Type (Type-I)
IRD-152
113 - 164
CPRNC
148 - 152
DPRNP
141 - 145
H-L Type (Type-I)
IRD-152
403 - 454
CPRNC
438 - 442
DPRNP
431 - 435
H-L Type (Type-I)
IRD-152
55 - 106
CPRNC
90 - 94
DPRNP
83 - 87
H-L Type (Type-I)
IRD-152
345 - 396
CPRNC
380 - 384
DPRNP
373 - 377
H-L Type (Type-I)
IRD-152
287 - 338
CPRNC
322 - 326
DPRNP
315 - 319
H-L Type (Type-I)
IRD-153
577 - 628
CPRNC
612 - 616
DPRNP
605 - 609
H-L Type (Type-I)
IRD-251
519 - 570
CTLNC
554 - 558
DPRNP
547 - 551
H-L Type (Type-I)
IRD-604
262 - 312
CPRNC
264 - 268
EEKKN
281 - 285
L-H Type (Type-II)
IRD-604
204 - 254
CPRNC
206 - 210
EEKKN
223 - 227
L-H Type (Type-II)
IRD-604
146 - 196
CPRNC
148 - 152
EEKKN
165 - 169
L-H Type (Type-II)
IRD-604
436 - 486
CPRNC
438 - 442
EEKKN
455 - 459
L-H Type (Type-II)
IRD-604
88 - 138
CPRNC
90 - 94
EEKKN
107 - 111
L-H Type (Type-II)
IRD-604
378 - 428
CPRNC
380 - 384
EEKKN
397 - 401
L-H Type (Type-II)
IRD-604
320 - 370
CPRNC
322 - 326
EEKKN
339 - 343
L-H Type (Type-II)
IRD-605
494 - 544
CPRNC
496 - 500
EEKKN
513 - 517
L-H Type (Type-II)
IRD-606
610 - 660
CPRNC
612 - 616
EEKKN
629 - 633
L-H Type (Type-II)
IRD-655
30 - 80
CPLNC
32 - 36
EEKKN
49 - 53
L-H Type (Type-II)
IRD-658
552 - 602
CTLNC
554 - 558
EEKKN
571 - 575
L-H Type (Type-II)
Domain(
IRD-152
)
:
RICTNCCAGTKGCKYFSDDGTFVCEGES
DPRNP
KA
CPRNC
DPRIAYGICPLS
Reactive Loop(RCL)
:
CPRNC
Linker
:
DPRNP
Domain Type
:
H-L Type (Type-I)
Disulphide Bond
:
3,40 ; 6,24 ; 7,36 ; 13,49
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
R
I
C
T
N
C
C
A
G
T
K
G
C
K
Y
F
S
D
D
G
T
F
V
C
E
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
I
C
P
L
S
Domain(
IRD-152
)
:
RICTNCCAGTKGCKYFSDDGTFVCEGES
DPRNP
KA
CPRNC
DPRIAYGICPLS
Reactive Loop(RCL)
:
CPRNC
Linker
:
DPRNP
Domain Type
:
H-L Type (Type-I)
Disulphide Bond
:
3,40 ; 6,24 ; 7,36 ; 13,49
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
R
I
C
T
N
C
C
A
G
T
K
G
C
K
Y
F
S
D
D
G
T
F
V
C
E
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
I
C
P
L
S
Domain(
IRD-152
)
:
RICTNCCAGTKGCKYFSDDGTFVCEGES
DPRNP
KA
CPRNC
DPRIAYGICPLS
Reactive Loop(RCL)
:
CPRNC
Linker
:
DPRNP
Domain Type
:
H-L Type (Type-I)
Disulphide Bond
:
3,40 ; 6,24 ; 7,36 ; 13,49
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
R
I
C
T
N
C
C
A
G
T
K
G
C
K
Y
F
S
D
D
G
T
F
V
C
E
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
I
C
P
L
S
Domain(
IRD-152
)
:
RICTNCCAGTKGCKYFSDDGTFVCEGES
DPRNP
KA
CPRNC
DPRIAYGICPLS
Reactive Loop(RCL)
:
CPRNC
Linker
:
DPRNP
Domain Type
:
H-L Type (Type-I)
Disulphide Bond
:
3,40 ; 6,24 ; 7,36 ; 13,49
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
R
I
C
T
N
C
C
A
G
T
K
G
C
K
Y
F
S
D
D
G
T
F
V
C
E
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
I
C
P
L
S
Domain(
IRD-152
)
:
RICTNCCAGTKGCKYFSDDGTFVCEGES
DPRNP
KA
CPRNC
DPRIAYGICPLS
Reactive Loop(RCL)
:
CPRNC
Linker
:
DPRNP
Domain Type
:
H-L Type (Type-I)
Disulphide Bond
:
3,40 ; 6,24 ; 7,36 ; 13,49
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
R
I
C
T
N
C
C
A
G
T
K
G
C
K
Y
F
S
D
D
G
T
F
V
C
E
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
I
C
P
L
S
Domain(
IRD-152
)
:
RICTNCCAGTKGCKYFSDDGTFVCEGES
DPRNP
KA
CPRNC
DPRIAYGICPLS
Reactive Loop(RCL)
:
CPRNC
Linker
:
DPRNP
Domain Type
:
H-L Type (Type-I)
Disulphide Bond
:
3,40 ; 6,24 ; 7,36 ; 13,49
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
R
I
C
T
N
C
C
A
G
T
K
G
C
K
Y
F
S
D
D
G
T
F
V
C
E
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
I
C
P
L
S
Domain(
IRD-152
)
:
RICTNCCAGTKGCKYFSDDGTFVCEGES
DPRNP
KA
CPRNC
DPRIAYGICPLS
Reactive Loop(RCL)
:
CPRNC
Linker
:
DPRNP
Domain Type
:
H-L Type (Type-I)
Disulphide Bond
:
3,40 ; 6,24 ; 7,36 ; 13,49
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
R
I
C
T
N
C
C
A
G
T
K
G
C
K
Y
F
S
D
D
G
T
F
V
C
E
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
I
C
P
L
S
Domain(
IRD-152
)
:
RICTNCCAGTKGCKYFSDDGTFVCEGES
DPRNP
KA
CPRNC
DPRIAYGICPLS
Reactive Loop(RCL)
:
CPRNC
Linker
:
DPRNP
Domain Type
:
H-L Type (Type-I)
Disulphide Bond
:
3,40 ; 6,24 ; 7,36 ; 13,49
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
R
I
C
T
N
C
C
A
G
T
K
G
C
K
Y
F
S
D
D
G
T
F
V
C
E
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
I
C
P
L
S
Domain(
IRD-153
)
:
RICTNCCAGKKGCKYFSDDGTFVCEGES
DPRNP
KA
CPRNC
DGRIAYGICPLS
Reactive Loop(RCL)
:
CPRNC
Linker
:
DPRNP
Domain Type
:
H-L Type (Type-I)
Disulphide Bond
:
3,40 ; 6,24 ; 7,36 ; 13,49
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
R
I
C
T
N
C
C
A
G
K
K
G
C
K
Y
F
S
D
D
G
T
F
V
C
E
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
G
R
I
A
Y
G
I
C
P
L
S
Domain(
IRD-251
)
:
RICTNCCAGTKGCKYFSNDGTFVCEGES
DPRNP
KA
CTLNC
DPRIAYGICPLS
Reactive Loop(RCL)
:
CTLNC
Linker
:
DPRNP
Domain Type
:
H-L Type (Type-I)
Disulphide Bond
:
3,40 ; 6,24 ; 7,36 ; 13,49
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
R
I
C
T
N
C
C
A
G
T
K
G
C
K
Y
F
S
N
D
G
T
F
V
C
E
G
E
S
D
P
R
N
P
K
A
C
T
L
N
C
D
P
R
I
A
Y
G
I
C
P
L
S
Domain(
IRD-604
)
:
KA
CPRNC
DPRIAYGICPLS
EEKKN
DRICTNCCAGTKGCKYFSDDGTFVCEG
Reactive Loop(RCL)
:
CPRNC
Linker
:
EEKKN
Domain Type
:
L-H Type (Type-II)
Disulphide Bond
:
3,28 ; 7,32 ; 16,38 ; 31,49
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
I
C
P
L
S
E
E
K
K
N
D
R
I
C
T
N
C
C
A
G
T
K
G
C
K
Y
F
S
D
D
G
T
F
V
C
E
G
Domain(
IRD-604
)
:
KA
CPRNC
DPRIAYGICPLS
EEKKN
DRICTNCCAGTKGCKYFSDDGTFVCEG
Reactive Loop(RCL)
:
CPRNC
Linker
:
EEKKN
Domain Type
:
L-H Type (Type-II)
Disulphide Bond
:
3,28 ; 7,32 ; 16,38 ; 31,49
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
I
C
P
L
S
E
E
K
K
N
D
R
I
C
T
N
C
C
A
G
T
K
G
C
K
Y
F
S
D
D
G
T
F
V
C
E
G
Domain(
IRD-604
)
:
KA
CPRNC
DPRIAYGICPLS
EEKKN
DRICTNCCAGTKGCKYFSDDGTFVCEG
Reactive Loop(RCL)
:
CPRNC
Linker
:
EEKKN
Domain Type
:
L-H Type (Type-II)
Disulphide Bond
:
3,28 ; 7,32 ; 16,38 ; 31,49
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
I
C
P
L
S
E
E
K
K
N
D
R
I
C
T
N
C
C
A
G
T
K
G
C
K
Y
F
S
D
D
G
T
F
V
C
E
G
Domain(
IRD-604
)
:
KA
CPRNC
DPRIAYGICPLS
EEKKN
DRICTNCCAGTKGCKYFSDDGTFVCEG
Reactive Loop(RCL)
:
CPRNC
Linker
:
EEKKN
Domain Type
:
L-H Type (Type-II)
Disulphide Bond
:
3,28 ; 7,32 ; 16,38 ; 31,49
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
I
C
P
L
S
E
E
K
K
N
D
R
I
C
T
N
C
C
A
G
T
K
G
C
K
Y
F
S
D
D
G
T
F
V
C
E
G
Domain(
IRD-604
)
:
KA
CPRNC
DPRIAYGICPLS
EEKKN
DRICTNCCAGTKGCKYFSDDGTFVCEG
Reactive Loop(RCL)
:
CPRNC
Linker
:
EEKKN
Domain Type
:
L-H Type (Type-II)
Disulphide Bond
:
3,28 ; 7,32 ; 16,38 ; 31,49
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
I
C
P
L
S
E
E
K
K
N
D
R
I
C
T
N
C
C
A
G
T
K
G
C
K
Y
F
S
D
D
G
T
F
V
C
E
G
Domain(
IRD-604
)
:
KA
CPRNC
DPRIAYGICPLS
EEKKN
DRICTNCCAGTKGCKYFSDDGTFVCEG
Reactive Loop(RCL)
:
CPRNC
Linker
:
EEKKN
Domain Type
:
L-H Type (Type-II)
Disulphide Bond
:
3,28 ; 7,32 ; 16,38 ; 31,49
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
I
C
P
L
S
E
E
K
K
N
D
R
I
C
T
N
C
C
A
G
T
K
G
C
K
Y
F
S
D
D
G
T
F
V
C
E
G
Domain(
IRD-604
)
:
KA
CPRNC
DPRIAYGICPLS
EEKKN
DRICTNCCAGTKGCKYFSDDGTFVCEG
Reactive Loop(RCL)
:
CPRNC
Linker
:
EEKKN
Domain Type
:
L-H Type (Type-II)
Disulphide Bond
:
3,28 ; 7,32 ; 16,38 ; 31,49
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
I
C
P
L
S
E
E
K
K
N
D
R
I
C
T
N
C
C
A
G
T
K
G
C
K
Y
F
S
D
D
G
T
F
V
C
E
G
Domain(
IRD-605
)
:
KA
CPRNC
DPRIAYGICPLS
EEKKN
DRICTNCCAGTKGCKYFSNDGTFVCEG
Reactive Loop(RCL)
:
CPRNC
Linker
:
EEKKN
Domain Type
:
L-H Type (Type-II)
Disulphide Bond
:
3,28 ; 7,32 ; 16,38 ; 31,49
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
I
C
P
L
S
E
E
K
K
N
D
R
I
C
T
N
C
C
A
G
T
K
G
C
K
Y
F
S
N
D
G
T
F
V
C
E
G
Domain(
IRD-606
)
:
KA
CPRNC
DGRIAYGICPLS
EEKKN
DRICTNCCAGKKGCKYFSDDGTFICEG
Reactive Loop(RCL)
:
CPRNC
Linker
:
EEKKN
Domain Type
:
L-H Type (Type-II)
Disulphide Bond
:
3,28 ; 7,32 ; 16,38 ; 31,49
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
K
A
C
P
R
N
C
D
G
R
I
A
Y
G
I
C
P
L
S
E
E
K
K
N
D
R
I
C
T
N
C
C
A
G
K
K
G
C
K
Y
F
S
D
D
G
T
F
I
C
E
G
Domain(
IRD-655
)
:
KA
CPLNC
DPRIAYGVCPRS
EEKKN
DRICTNCCAGTKGCKYFSDDGTFVCEG
Reactive Loop(RCL)
:
CPLNC
Linker
:
EEKKN
Domain Type
:
L-H Type (Type-II)
Disulphide Bond
:
3,28 ; 7,32 ; 16,38 ; 31,49
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
K
A
C
P
L
N
C
D
P
R
I
A
Y
G
V
C
P
R
S
E
E
K
K
N
D
R
I
C
T
N
C
C
A
G
T
K
G
C
K
Y
F
S
D
D
G
T
F
V
C
E
G
Domain(
IRD-658
)
:
KA
CTLNC
DPRIAYGICPLS
EEKKN
DRICTNCCAGKKGCKYFSDDGTFVCEG
Reactive Loop(RCL)
:
CTLNC
Linker
:
EEKKN
Domain Type
:
L-H Type (Type-II)
Disulphide Bond
:
3,28 ; 7,32 ; 16,38 ; 31,49
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
K
A
C
T
L
N
C
D
P
R
I
A
Y
G
I
C
P
L
S
E
E
K
K
N
D
R
I
C
T
N
C
C
A
G
K
K
G
C
K
Y
F
S
D
D
G
T
F
V
C
E
G
DOMAINS ARCHITECTURE
Domain
Position
Length
Architecture
IRD-152
229 - 280
52
IRD-152
171 - 222
52
IRD-152
461 - 512
52
IRD-152
113 - 164
52
IRD-152
403 - 454
52
IRD-152
55 - 106
52
IRD-152
345 - 396
52
IRD-152
287 - 338
52
IRD-153
577 - 628
52
IRD-251
519 - 570
52
IRD-604
262 - 312
51
IRD-604
204 - 254
51
IRD-604
146 - 196
51
IRD-604
436 - 486
51
IRD-604
88 - 138
51
IRD-604
378 - 428
51
IRD-604
320 - 370
51
IRD-605
494 - 544
51
IRD-606
610 - 660
51
IRD-655
30 - 80
51
IRD-658
552 - 602
51
Amino Acid
Count
% by Frequency
Alanine
39
5.68
Cysteine
88
12.81
Aspartic acid
56
8.15
Glutamic acid
49
7.13
Phenylalanine
23
3.35
Glycine
57
8.3
Histidine
2
0.29
Isoleucine
33
4.8
Lysine
60
8.73
Leucine
21
3.06
Methionine
2
0.29
Asparagine
46
6.7
Proline
51
7.42
Glutamine
1
0.15
Arginine
44
6.4
Serine
39
5.68
Threonine
32
4.66
Valine
20
2.91
Tryptophan
0
0
Tyrosine
24
3.49
Architecture
×
Signal Peptide
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298
299
300
301
302
303
304
305
306
307
308
309
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
352
353
354
355
356
357
358
359
360
361
362
363
364
365
366
367
368
369
370
371
372
373
374
375
376
377
378
379
380
381
382
383
384
385
386
387
388
389
390
391
392
393
394
395
396
397
398
399
400
401
402
403
404
405
406
407
408
409
410
411
412
413
414
415
416
417
418
419
420
421
422
423
424
425
426
427
428
429
430
431
432
433
434
435
436
437
438
439
440
441
442
443
444
445
446
447
448
449
450
451
452
453
454
455
456
457
458
459
460
461
462
463
464
465
466
467
468
469
470
471
472
473
474
475
476
477
478
479
480
481
482
483
484
485
486
487
488
489
490
491
492
493
494
495
496
497
498
499
500
501
502
503
504
505
506
507
508
509
510
511
512
513
514
515
516
517
518
519
520
521
522
523
524
525
526
527
528
529
530
531
532
533
534
535
536
537
538
539
540
541
542
543
544
545
546
547
548
549
550
551
552
553
554
555
556
557
558
559
560
561
562
563
564
565
566
567
568
569
570
571
572
573
574
575
576
577
578
579
580
581
582
583
584
585
586
587
588
589
590
591
592
593
594
595
596
597
598
599
600
601
602
603
604
605
606
607
608
609
610
611
612
613
614
615
616
617
618
619
620
621
622
623
624
625
626
627
628
629
630
631
632
633
634
635
636
637
638
639
640
641
642
643
644
645
646
647
648
649
650
651
652
653
654
655
656
657
658
659
660
661
662
663
664
665
666
667
668
669
670
671
672
673
674
675
676
677
678
679
680
681
682
683
684
685
686
687
M
A
V
H
R
V
S
F
L
A
L
L
L
L
L
G
M
S
L
L
V
S
N
V
E
H
A
D
A
K
A
C
P
L
N
C
D
P
R
I
A
Y
G
V
C
P
R
S
E
E
K
K
N
D
R
I
C
T
N
C
C
A
G
T
K
G
C
K
Y
F
S
D
D
G
T
F
V
C
E
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
I
C
P
L
S
E
E
K
K
N
D
R
I
C
T
N
C
C
A
G
T
K
G
C
K
Y
F
S
D
D
G
T
F
V
C
E
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
I
C
P
L
S
E
E
K
K
N
D
R
I
C
T
N
C
C
A
G
T
K
G
C
K
Y
F
S
D
D
G
T
F
V
C
E
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
I
C
P
L
S
E
E
K
K
N
D
R
I
C
T
N
C
C
A
G
T
K
G
C
K
Y
F
S
D
D
G
T
F
V
C
E
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
I
C
P
L
S
E
E
K
K
N
D
R
I
C
T
N
C
C
A
G
T
K
G
C
K
Y
F
S
D
D
G
T
F
V
C
E
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
I
C
P
L
S
E
E
K
K
N
D
R
I
C
T
N
C
C
A
G
T
K
G
C
K
Y
F
S
D
D
G
T
F
V
C
E
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
I
C
P
L
S
E
E
K
K
N
D
R
I
C
T
N
C
C
A
G
T
K
G
C
K
Y
F
S
D
D
G
T
F
V
C
E
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
I
C
P
L
S
E
E
K
K
N
D
R
I
C
T
N
C
C
A
G
T
K
G
C
K
Y
F
S
D
D
G
T
F
V
C
E
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
I
C
P
L
S
E
E
K
K
N
D
R
I
C
T
N
C
C
A
G
T
K
G
C
K
Y
F
S
N
D
G
T
F
V
C
E
G
E
S
D
P
R
N
P
K
A
C
T
L
N
C
D
P
R
I
A
Y
G
I
C
P
L
S
E
E
K
K
N
D
R
I
C
T
N
C
C
A
G
K
K
G
C
K
Y
F
S
D
D
G
T
F
V
C
E
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
G
R
I
A
Y
G
I
C
P
L
S
E
E
K
K
N
D
R
I
C
T
N
C
C
A
G
K
K
G
C
K
Y
F
S
D
D
G
T
F
I
C
E
G
E
S
E
Y
A
S
K
V
D
E
Y
V
R
E
V
E
N
D
L
Q
K
S
K
V
A
V
S
A
V
H
R
V
S
F
L
A
L
L
L
L
L
G
M
S
L
L
V
S
N
V
E
H
A
D
A
K
Domains
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298
299
300
301
302
303
304
305
306
307
308
309
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
352
353
354
355
356
357
358
359
360
361
362
363
364
365
366
367
368
369
370
371
372
373
374
375
376
377
378
379
380
381
382
383
384
385
386
387
388
389
390
391
392
393
394
395
396
397
398
399
400
401
402
403
404
405
406
407
408
409
410
411
412
413
414
415
416
417
418
419
420
421
422
423
424
425
426
427
428
429
430
431
432
433
434
435
436
437
438
439
440
441
442
443
444
445
446
447
448
449
450
451
452
453
454
455
456
457
458
459
460
461
462
463
464
465
466
467
468
469
470
471
472
473
474
475
476
477
478
479
480
481
482
483
484
485
486
487
488
489
490
491
492
493
494
495
496
497
498
499
500
501
502
503
504
505
506
507
508
509
510
511
512
513
514
515
516
517
518
519
520
521
522
523
524
525
526
527
528
529
530
531
532
533
534
535
536
537
538
539
540
541
542
543
544
545
546
547
548
549
550
551
552
553
554
555
556
557
558
559
560
561
562
563
564
565
566
567
568
569
570
571
572
573
574
575
576
577
578
579
580
581
582
583
584
585
586
587
588
589
590
591
592
593
594
595
596
597
598
599
600
601
602
603
604
605
606
607
608
609
610
611
612
613
614
615
616
617
618
619
620
621
622
623
624
625
626
627
628
629
630
631
632
633
634
635
636
637
638
639
640
641
642
643
644
645
646
647
648
649
650
651
652
653
654
655
656
657
658
659
660
661
662
663
664
665
666
667
668
669
670
671
672
673
674
675
676
677
678
679
680
681
682
683
684
685
686
687
M
A
V
H
R
V
S
F
L
A
L
L
L
L
L
G
M
S
L
L
V
S
N
V
E
H
A
D
A
K
A
C
P
L
N
C
D
P
R
I
A
Y
G
V
C
P
R
S
E
E
K
K
N
D
R
I
C
T
N
C
C
A
G
T
K
G
C
K
Y
F
S
D
D
G
T
F
V
C
E
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
I
C
P
L
S
E
E
K
K
N
D
R
I
C
T
N
C
C
A
G
T
K
G
C
K
Y
F
S
D
D
G
T
F
V
C
E
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
I
C
P
L
S
E
E
K
K
N
D
R
I
C
T
N
C
C
A
G
T
K
G
C
K
Y
F
S
D
D
G
T
F
V
C
E
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
I
C
P
L
S
E
E
K
K
N
D
R
I
C
T
N
C
C
A
G
T
K
G
C
K
Y
F
S
D
D
G
T
F
V
C
E
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
I
C
P
L
S
E
E
K
K
N
D
R
I
C
T
N
C
C
A
G
T
K
G
C
K
Y
F
S
D
D
G
T
F
V
C
E
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
I
C
P
L
S
E
E
K
K
N
D
R
I
C
T
N
C
C
A
G
T
K
G
C
K
Y
F
S
D
D
G
T
F
V
C
E
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
I
C
P
L
S
E
E
K
K
N
D
R
I
C
T
N
C
C
A
G
T
K
G
C
K
Y
F
S
D
D
G
T
F
V
C
E
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
I
C
P
L
S
E
E
K
K
N
D
R
I
C
T
N
C
C
A
G
T
K
G
C
K
Y
F
S
D
D
G
T
F
V
C
E
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
P
R
I
A
Y
G
I
C
P
L
S
E
E
K
K
N
D
R
I
C
T
N
C
C
A
G
T
K
G
C
K
Y
F
S
N
D
G
T
F
V
C
E
G
E
S
D
P
R
N
P
K
A
C
T
L
N
C
D
P
R
I
A
Y
G
I
C
P
L
S
E
E
K
K
N
D
R
I
C
T
N
C
C
A
G
K
K
G
C
K
Y
F
S
D
D
G
T
F
V
C
E
G
E
S
D
P
R
N
P
K
A
C
P
R
N
C
D
G
R
I
A
Y
G
I
C
P
L
S
E
E
K
K
N
D
R
I
C
T
N
C
C
A
G
K
K
G
C
K
Y
F
S
D
D
G
T
F
I
C
E
G
E
S
E
Y
A
S
K
V
D
E
Y
V
R
E
V
E
N
D
L
Q
K
S
K
V
A
V
S